Profile of the Running ES Score & Positions of GeneSet Members on the Rank Ordered List
| Dataset | expression_12hrs.Phenotype.cls #treated_versus_cont.Phenotype.cls #treated_versus_cont_repos |
| Phenotype | Phenotype.cls#treated_versus_cont_repos |
| Upregulated in class | cont |
| GeneSet | GO|GO:0043900 |
| Enrichment Score (ES) | -0.7084739 |
| Normalized Enrichment Score (NES) | -1.6686215 |
| Nominal p-value | 0.0028985508 |
| FDR q-value | 0.17754406 |
| FWER p-Value | 0.991 |
| PROBE | DESCRIPTION (from dataset) | GENE SYMBOL | GENE_TITLE | RANK IN GENE LIST | RANK METRIC SCORE | RUNNING ES | CORE ENRICHMENT | |
|---|---|---|---|---|---|---|---|---|
| 1 | 1175 | "AP2S1 (adaptor-related protein complex 2, sigma 1 subunit)" | 1777 | 21.343 | -0.0682 | No | ||
| 2 | 162 | "AP1B1 (adaptor-related protein complex 1, beta 1 subunit)" | 2020 | 18.565 | -0.0632 | No | ||
| 3 | 8905 | "AP1S2 (adaptor-related protein complex 1, sigma 2 subunit)" | 2240 | 16.745 | -0.0587 | No | ||
| 4 | 6895 | TARBP2 (TAR (HIV-1) RNA binding protein 2) | 2251 | 16.637 | -0.0440 | No | ||
| 5 | 163 | "AP2B1 (adaptor-related protein complex 2, beta 1 subunit)" | 2511 | 14.197 | -0.0438 | No | ||
| 6 | 161 | "AP2A2 (adaptor-related protein complex 2, alpha 2 subunit)" | 2544 | 13.921 | -0.0326 | No | ||
| 7 | 4277 | MICB (MHC class I polypeptide-related sequence B) | 2688 | 12.937 | -0.0279 | No | ||
| 8 | 8907 | "AP1M1 (adaptor-related protein complex 1, mu 1 subunit)" | 3145 | 10.205 | -0.0410 | No | ||
| 9 | 130340 | "AP1S3 (adaptor-related protein complex 1, sigma 3 subunit)" | 3774 | 7.615 | -0.0651 | No | ||
| 10 | 51191 | HERC5 (hect domain and RLD 5) | 4140 | 6.303 | -0.0773 | No | ||
| 11 | 2534 | "FYN (FYN oncogene related to SRC, FGR, YES)" | 4244 | 5.992 | -0.0769 | No | ||
| 12 | 7187 | TRAF3 (TNF receptor-associated factor 3) | 4328 | 5.691 | -0.0758 | No | ||
| 13 | 255520 | ELMOD2 (ELMO/CED-12 domain containing 2) | 4514 | 5.198 | -0.0802 | No | ||
| 14 | 1174 | "AP1S1 (adaptor-related protein complex 1, sigma 1 subunit)" | 4682 | 4.756 | -0.0841 | No | ||
| 15 | 160 | "AP2A1 (adaptor-related protein complex 2, alpha 1 subunit)" | 4698 | 4.725 | -0.0805 | No | ||
| 16 | 2208 | "FCER2 (Fc fragment of IgE, low affinity II, receptor for (CD23))" | 5116 | 3.777 | -0.0976 | No | ||
| 17 | 4843 | "NOS2A (nitric oxide synthase 2A (inducible, hepatocytes))" | 5502 | 3.060 | -0.1138 | No | ||
| 18 | 60489 | "APOBEC3G (apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 3G)" | 5820 | 2.589 | -0.1271 | No | ||
| 19 | 2150 | F2RL1 (coagulation factor II (thrombin) receptor-like 1) | 5923 | 2.465 | -0.1299 | No | ||
| 20 | 222537 | HS3ST5 (heparan sulfate (glucosamine) 3-O-sulfotransferase 5) | 5984 | 2.392 | -0.1307 | No | ||
| 21 | 820 | CAMP (cathelicidin antimicrobial peptide) | 6949 | 1.377 | -0.1770 | No | ||
| 22 | 149233 | IL23R (interleukin 23 receptor) | 7228 | 1.174 | -0.1896 | No | ||
| 23 | 340061 | TMEM173 (transmembrane protein 173) | 7361 | 1.090 | -0.1951 | No | ||
| 24 | 83737 | ITCH (itchy E3 ubiquitin protein ligase homolog (mouse)) | 7590 | 0.949 | -0.2055 | No | ||
| 25 | 3932 | LCK (lymphocyte-specific protein tyrosine kinase) | 8602 | 0.511 | -0.2550 | No | ||
| 26 | 54476 | RNF216 (ring finger protein 216) | 9832 | 0.174 | -0.3154 | No | ||
| 27 | 3458 | "IFNG (interferon, gamma)" | 9835 | 0.174 | -0.3154 | No | ||
| 28 | 919 | CD247 (CD247 molecule) | 9865 | 0.167 | -0.3167 | No | ||
| 29 | 3593 | "IL12B (interleukin 12B (natural killer cell stimulatory factor 2, cytotoxic lymphocyte maturation factor 2, p40))" | 11374 | -0.185 | -0.3909 | No | ||
| 30 | 940 | CD28 (CD28 molecule) | 12034 | -0.333 | -0.4231 | No | ||
| 31 | 4153 | "MBL2 (mannose-binding lectin (protein C) 2, soluble (opsonic defect))" | 12147 | -0.357 | -0.4283 | No | ||
| 32 | 5027 | "P2RX7 (purinergic receptor P2X, ligand-gated ion channel, 7)" | 12248 | -0.386 | -0.4329 | No | ||
| 33 | 920 | CD4 (CD4 molecule) | 12457 | -0.446 | -0.4428 | No | ||
| 34 | 55894 | "DEFB103A (defensin, beta 103A)" | 12657 | -0.500 | -0.4521 | No | ||
| 35 | 163702 | "IL28RA (interleukin 28 receptor, alpha (interferon, lambda receptor))" | 13920 | -0.961 | -0.5135 | No | ||
| 36 | 1794 | DOCK2 (dedicator of cytokinesis 2) | 14135 | -1.064 | -0.5231 | No | ||
| 37 | 926 | CD8B (CD8b molecule) | 14383 | -1.176 | -0.5342 | No | ||
| 38 | 9844 | ELMO1 (engulfment and cell motility 1) | 14392 | -1.178 | -0.5335 | No | ||
| 39 | 7128 | "TNFAIP3 (tumor necrosis factor, alpha-induced protein 3)" | 14654 | -1.331 | -0.5452 | No | ||
| 40 | 3456 | "IFNB1 (interferon, beta 1, fibroblast)" | 14732 | -1.384 | -0.5477 | No | ||
| 41 | 3594 | "IL12RB1 (interleukin 12 receptor, beta 1)" | 15945 | -2.429 | -0.6053 | No | ||
| 42 | 3055 | HCK (hemopoietic cell kinase) | 16018 | -2.517 | -0.6066 | No | ||
| 43 | 200316 | "APOBEC3F (apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 3F)" | 17527 | -5.737 | -0.6757 | No | ||
| 44 | 114609 | TIRAP (toll-interleukin 1 receptor (TIR) domain containing adaptor protein) | 17660 | -6.248 | -0.6766 | No | ||
| 45 | 10053 | "AP1M2 (adaptor-related protein complex 1, mu 2 subunit)" | 17870 | -7.186 | -0.6803 | No | ||
| 46 | 59307 | SIGIRR (single immunoglobulin and toll-interleukin 1 receptor (TIR) domain) | 18442 | -10.737 | -0.6987 | Yes | ||
| 47 | 5371 | PML (promyelocytic leukemia) | 18450 | -10.797 | -0.6891 | Yes | ||
| 48 | 51606 | "ATP6V1H (ATPase, H+ transporting, lysosomal 50/57kDa, V1 subunit H)" | 18782 | -13.854 | -0.6928 | Yes | ||
| 49 | 51561 | "IL23A (interleukin 23, alpha subunit p19)" | 19029 | -17.353 | -0.6891 | Yes | ||
| 50 | 10221 | TRIB1 (tribbles homolog 1 (Drosophila)) | 19194 | -20.406 | -0.6785 | Yes | ||
| 51 | 23586 | DDX58 (DEAD (Asp-Glu-Ala-Asp) box polypeptide 58) | 19385 | -25.182 | -0.6649 | Yes | ||
| 52 | 375 | ARF1 (ADP-ribosylation factor 1) | 19469 | -27.515 | -0.6439 | Yes | ||
| 53 | 55690 | PACS1 (phosphofurin acidic cluster sorting protein 1) | 19567 | -30.534 | -0.6207 | Yes | ||
| 54 | 5879 | "RAC1 (ras-related C3 botulinum toxin substrate 1 (rho family, small GTP binding protein Rac1))" | 19612 | -32.214 | -0.5935 | Yes | ||
| 55 | 57506 | VISA (virus-induced signaling adapter) | 19622 | -32.677 | -0.5641 | Yes | ||
| 56 | 5062 | PAK2 (p21 protein (Cdc42/Rac)-activated kinase 2) | 19777 | -40.918 | -0.5343 | Yes | ||
| 57 | 164 | "AP1G1 (adaptor-related protein complex 1, gamma 1 subunit)" | 19805 | -42.696 | -0.4966 | Yes | ||
| 58 | 1173 | "AP2M1 (adaptor-related protein complex 2, mu 1 subunit)" | 19821 | -43.932 | -0.4572 | Yes | ||
| 59 | 5094 | PCBP2 (poly(rC) binding protein 2) | 20076 | -73.183 | -0.4028 | Yes | ||
| 60 | 567 | B2M (beta-2-microglobulin) | 20305 | -220.982 | -0.2121 | Yes | ||
| 61 | 3434 | IFIT1 (interferon-induced protein with tetratricopeptide repeats 1) | 20306 | -233.172 | 0.0009 | Yes |
